Publication details
- Journal: Journal of Bone and Mineral Research, vol. 33, p. 228–228, 2018
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International Standard Numbers:
- Printed: 0884-0431
- Electronic: 1523-4681
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Links:
- SAMMENDRAG: www.researchgate.net/publication/328316196_Distinct_subsets_of_non-coding_RNAs_including_miRNAs_are_associated_with_BMD_in_stressed_and_unstressed_bone
- OMTALE: www.researchgate.net/publication/328316196_Distinct_subsets_of_non-coding_RNAs_including_miRNAs_are_associated_with_BMD_in_stressed_and_unstressed_bone
The causes and molecular pathogenesis of postmenopausal osteoporosis (PMO) are far from understood even though osteoporotic fractures affect almost 50% of women above 50 years of age, resulting in e.g. femoral neck fractures imposing high risk to normal life. We addressed this issue by characterizing the global non-coding RNA (ncRNA) transcriptomes in non-weight bearing (unstressed) iliac and weight bearing (stressed) femoral postmenopausal bone across BMDs varying from normal (T-score >-1.0) to osteoporotic (T-score ≤ -2.5). The analyses were performed on transiliacal (84) and femoral trochanter (18) bone biopsies. Nearly 700 iliac bone ncRNAs were determined by a PCR based method and more than 6600 femoral ncRNAs were accessed by Affymetrix microchip analysis. BMD associations were calculated by linear regression and validated by Lasso analysis. DIANA TOOLS – mirPath v.3 software was used to identify overrepresented signaling pathways among the BMD associated transcripts at the two different sites.