Investigating Time-Varying Predictor Effects on Cardiovascular Outcomes in Breast Cancer Survivors

Relevant factors can have shifting prognostic impacts on cardiovascular disease (CVD) occurrences among in patients with breast cancer (BC) over time. CVD incidence and its driving factors vary among different CVDs. We examined the time to the first occurrence of heart attack, atrial fibrillation, embolic stroke, angina pectoris, embolism, peripheral vascular disease, and heart failure (HF). We particularly focused on the influence of molecular subtype, adjusting for age, tumor stage, and radiation therapy.