The Genomic HyperBrowser: inferential genomics at the sequence level

  • Geir Kjetil Sandve
  • Sveinung Gundersen
  • Halfdan Rydbeck
  • Ingrid Kristine Glad
  • Lars Holden


The immense increase in the generation of genomic scale data poses an unmet analytical challenge, due to a lack of established methodology with the required flexibility and power. We propose a first principled approach to statistical analysis of sequence-level genomic information. We provide a growing collection of generic biological investigations that query pairwise relations between tracks, represented as mathematical objects, along the genome. The Genomic HyperBrowser implements the approach and is available at