Vitenskapelig artikkel   2020

Hubin, Aliaksandr; Storvik, Geir Olve; Grini, Paul Eivind; Butenko, Melinka Alonso

Publikasjonsdetaljer

Tidsskrift:

Austrian Journal of Statistics, vol. 49, p. 46–56–11, mandag 13. april 2020

Utgave:

4

Internasjonale standardnumre:

Trykt: 1026-597X

Lenker:

FULLTEKST: www.ajs.or.at/index.php/ajs/article/view/1124/696
DATA: www.ajs.or.at/index.php/ajs/article/view/1124
ARKIV: http://hdl.handle.net/10852/78195
DOI: doi.org/10.17713/ajs.v49i4.1124

Epigenetic observations are represented by the total number of reads from a given pool of cells and the number of methylated reads, making it reasonable to model this data by a binomial distribution. There are numerous factors that can influence the probability of success in a particular region. Moreover, there is a strong spatial (alongside the genome) dependence of these probabilities. We incorporate dependence on the covariates and the spatial dependence of the methylation probability for observations from a pool of cells by means of a binomial regression model with a latent Gaussian field and a logit link function. We apply a Bayesian approach including prior specifications on model configurations. We run a mode jumping Markov chain Monte Carlo algorithm (MJMCMC) across different choices of covariates in order to obtain the joint posterior distribution of parameters and models. This also allows finding the best set of covariates to model methylation probability within the genomic region of interest and individual marginal inclusion probabilities of the covariates.